HCID 13561778, compound → HCID 13561779, compound

HRID 1380368Notes

Reaction equation

HRID 1380368 reaction equation
[N+:1]([C:4]1[CH:16]=[C:15]2[C:7]([C:8]3[CH:9]=[CH:10][C:11]([CH2:17][CH2:18][C:19](=[O:21])[CH3:20])=[CH:12][C:13]=3[CH2:14]2)=[CH:6][CH:5]=1)([O-])=O>CO>[NH2:1][C:4]1[CH:16]=[C:15]2[C:7]([C:8]3[CH:9]=[CH:10][C:11]([CH2:17][CH2:18][C:19](=[O:21])[CH3:20])=[CH:12][C:13]=3[CH2:14]2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 13561778HCID 13561778, compound

Product 1

HCID 13561779HCID 13561779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 400 ml of methanol were added 5.62 grams of 4-(7-nitro-2-fluorenyl)-butan-2-one and 280 mg of platinic oxide (monohydrate) and subjected to catalytic reduction at ordinary pressure. The catalyst was removed by filtration and methanol was removed by evaporation in vacuo. To the residue was added small amount of methanol and the crystals separated out were collected by filtration to give 4-(7-amino-2-fluorenyl)-butan-2-one, m.p. 116°-117° C.

Workup

  1. customThe catalyst was removed by filtration and methanol
  2. customwas removed by evaporation in vacuo
  3. additionTo the residue was added small amount of methanol
  4. customthe crystals separated out
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-d900846452bb41279f07a11f2d64a6bd
Source dataset
uspto-grants-1986_04
Patent number
US04581377

Reaction notes

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