Sodium Hydroxide → HCID 13561795, compound

HRID 1380374Notes

Reaction equation

HRID 1380374 reaction equation
[OH-].[Na+].C([O:6][CH:7]([CH2:9][CH2:10][C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14](=[O:24])[C:13]=2[CH:12]=1)[CH3:8])(=O)C>CO.O>[O:24]=[C:14]1[C:13]2[CH:12]=[C:11]([CH2:10][CH2:9][CH:7]([OH:6])[CH3:8])[CH:23]=[CH:22][C:21]=2[C:20]2[C:15]1=[CH:16][CH:17]=[CH:18][CH:19]=2

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 13561794HCID 13561794, compound

Product 1

HCID 13561795HCID 13561795, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Sodium hydroxide (0.2 gram) was dissolved in a mixture of 20 ml of methanol and 5 ml of water, then 1.47 grams of 4-(9-oxo-2-fluorenyl)-butan-2-ol acetate was added thereto, and the mixture was heated to reflux for two hours. After removal of methanol by evaporation therefrom, chloroform was added to the residue, the mixture was washed with water, and dried with magnesium sulfate. Chlorform was evaporated therefrom and the residue was allowed to stand to give crystals. They were recrystallized from isopropyl ether to give 1.2 grams of 4-(9-oxo-2-fluorenyl)-butan-2-ol, yellow crystals, m.p. 77°-78° C.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for two hours
  3. customAfter removal of methanol
  4. customby evaporation
  5. additionchloroform was added to the residue
  6. washthe mixture was washed with water
  7. dry with materialdried with magnesium sulfate
  8. customChlorform was evaporated
  9. customto give crystals
  10. customThey were recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-e7f73b7819c7496a8140f21a55fd679f
Source dataset
uspto-grants-1986_04
Patent number
US04581377

Reaction notes

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