HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-Butyl-5-nitroso-6-aminouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 6-Amino-1-butyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 2428996 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Butyl-5-nitroso-6-aminouracil | HCID 10798570 | 84.8% |
Reaction Steps
91.5 g (0.5 mole) of 1-butyl-6-aminouracil are suspended in 1 liter of water in a reactor equipped with a magnetic stirrer. A solution of 38 g of sodium nitrite in 250 ml of water is added to the suspension. 65 ml of acetic acid are then run in dropwise with stirring, after which the mixture is stirred for 18 hours at ambient temperature. After cooling in an ice bath, the precipitate is filtered, giving 90 g of violet-coloured crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581451 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-1eb363a8fd5f4bcab6c04d2ec9f97af7 |
| Source note | uspto-grants-1986_04 |