Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-Butyl-3-isopropyl-6-chlorouracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Butyl-p-toluenesulfonate | HCID 13066 | — |
| 반응물 | 6-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 820107 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Butyl-3-isopropyl-6-chlorouracil | HCID 23326877 | 98.1% |
반응 단계
16.6 g (0.12 mole) of potassium carbonate and 24 g (0.105 mole) of butyl-p-toluene sulphonate are added to a solution of 19 g (0.10 mole) of 3-isopropyl-6-chlorouracil in 200 ml of dimethyl formamide. The mixture is heated for 1 hour to 80° C. After evaporation of the solvent, the residue is taken up in water, followed by extraction with CH2Cl2. The extract is dried over Na2SO4 and the solvent is evaporated, leaving 24 g of a pale yellow oily product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04581451 |
| 출처 데이터셋 | uspto-grants-1986_04 |
| ORD ID | ord-5b58ab43a8f7478da0398adfb7584e49 |
| 출처 메모 | uspto-grants-1986_04 |