HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 2-[(3-Nitrophenoxy)methyl]-1,3-benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Nitrophenol | HCID 11137 | — |
| Reactant | 2-(Chloromethyl)benzothiazole | HCID 304978 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-[(3-Nitrophenoxy)methyl]-1,3-benzothiazole | HCID 13631155 | 84% |
Reaction Steps
A mixture of 2-chloromethylbenzothiazole (17.6 g), 3-nitrophenol (13.2 g), cesium carbonate (30 g), sodium carbonate (10 g), potassium iodide (0.5 g) and acetone (600 ml) is heated at reflux overnight. The mixture is filtered and the resulting solution is partially concentrated. A crystalline solid forms which is filtered and dried, giving 22.8 g (84% yield), m.p. 156°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581457 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-e32d6cf4b94d492880a5e33541fa100d |
| Source note | uspto-grants-1986_04 |