Water → 5-(Bromomethyl)-1,2-oxazole-3-carboxylic acid

HRID 1380409Notes

Reaction equation

HRID 1380409 reaction equation
[Br:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8](Cl)=[O:9])[CH:4]=1.[OH2:11]>CC(C)=O>[Br:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([OH:9])=[O:11])[CH:4]=1

Participants

4

Reactant 2

HCID 962WaterHCID 133710215-(Bromomethyl)-3-isoxazolecarbonyl chloride

Product 1

HCID 133710205-(Bromomethyl)-1,2-oxazole-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
0 °C

Procedure

The distilled 5-(bromomethyl)-3-isoxazolecarbonyl chloride (1 g) is dissolved in 2 ml of acetone, cooled to 0° C. and 3 ml of water is added to the solution. The solution is allowed to stand at room temperature for one hour and then the solvent is removed under reduced pressure giving 0.9 g of the acid. It is dried over P2O5 for three days and has mp 143°-148° C.

Workup

  1. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-dc6addfd5adb42d8aef4524321e71581
Source dataset
uspto-grants-1986_04
Patent number
US04581458

Reaction notes

Loading…