HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 23326949, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 5,6-Dihydro-5-(trifluoromethyl)uracil | HCID 5638 | — |
| Reactant | Methyl trifluoromethyl ketone | HCID 9871 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 23326949 | HCID 23326949 | — |
Reaction Steps
One conventional method for synthesizing 5-trifluoromethyldihydrouracil comprises converting trifluoroacetone to cyanohydrin, acetylating the product, heat-decomposing the acetylated product, reacting the resulting alpha-trifluoroacrylonitrile with hydrogen bromide in methanol to form beta-bromo-alpha-trifluoromethylpropionamide, reacting the amide with urea or acetylurea, and cyclizing the resulting compound in hydrochloric acid [C. Heidelberger, D. G. Parsons and D. C. Remy, J. Med. Chem., 7, 1 (1964)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581452 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-2de6f4c489814505ab45a2b94c62795b |
| Source note | uspto-grants-1986_04 |