Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 2-(Trifluoromethyl)acrylic acid | HCID 587694 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13313788 | HCID 13313788 | 54% |
Reaction Steps
A mixture of α-trifluoromethylacrylic acid (700 mg; 5.0 mmoles) and urea (342 mg; 5.7 mmoles) in DMF (3 ml) was heated at 90° C. with stirring for 6 hours. DMF was evaporated under reduced pressure. The residue was purified by a column chromatography on silica gel (ethyl acetate) to give 540 mg (yield: 54%) of (2-hydroxycarbonyl-3,3,3-trifluoropropyl)urea. m.p.: 149°-149.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04581452 |
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| Source dataset | uspto-grants-1986_04 |
|---|
| ORD ID | ord-2a65ffed244a426281be9997a1ee26a2 |
|---|
| Source note | uspto-grants-1986_04 |
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