Dicyclohexylcarbodiimide → HCID 13313793, compound

Participants

Reaction Steps

A solution of DCC (206 mg; 1.0 mmole) in DMF (0.5 ml) was added dropwise to a solution of 1-(2-hydroxycarbonyl-3,3,3-trifluoropropyl)-3-phenylurea (276 mg; 1.0 mmole) obtained above in DMF (1 ml), and the mixture was stirred for 1 hour. The precipitated solid was filtered off, and washed with ethyl acetate. The solvents were evaporated under reduced pressure from the combined filtrates. The residue was purified by a column chromatography on silica gel (ethyl acetate:chloroform=1:3) to give 120 mg (yield: 47%) of 3-phenyl-5-trifluoromethyl-5,6-dihydrouracil. m.p.: 215°-216° C.

Provenance & Evidence