Dicyclohexylcarbodiimide → HCID 13313792, compound

Participants

Reaction Steps

A solution of DCC (430 mg; 2.1 mmoles) in DMF (1 ml) was added dropwise to a solution of 1-benzyl-3-(2-hydroxycarbonyl-3,3,3-trifluoropropyl)urea (580 mg; 2.0 mmoles) obtained above in DMF (2 ml). One hour later, the precipitated solid was filtered off and washed with ethyl acetate. The solvents were evaporated under reduced pressure from the combined filtrates. The residue was purified by a column chromatography on silica gel (ethyl acetate:chloroform=1:1) to give 468 mg (yield: 86%) of 3-benzyl-5-trifluoromethyl-5,6-dihydrouracil.

Provenance & Evidence