Acetic Anhydride → HCID 13313792, compound

Participants

Reaction Steps

Acetic anhydride (5 ml) was added to 290 mg (1.0 mmole) of 1-benzyl-3-(2-hydroxycarbonyl-3,3,3-trifluoropropyl)urea synthesized in Example 12, and the mixture was heated under reflux for 30 minutes. The solvent was evaporated under reduced pressure. The residue was purified by a column chromatography on silica gel (ethyl acetate:chloroform=1:1) to give 176 mg (yield: 65%) of 3-benzyl-5-trifluoromethyl-5,6-dihydrouracil.

Provenance & Evidence