Urea → 5,6-Dihydro-5-(trifluoromethyl)uracil

Participants

Reaction Conditions

Reaction Steps

A mixture of α-trifluoromethylacrylic acid (350 mg; 2.5 mmoles), urea (162 mg; 2.7 mmoles) and acetic anhydride (2 ml) was heated at 80° C. with stirring for 2 hours. After cooling to 0° C., the precipitated white solid was filtered off to give 210 mg (yield: 46%) of 5-trifluoromethyldihydrouracil. The solvent was evaporated under reduced pressure from the filtrate. The residue was crystallized from ethanol to give additional 95 mg (yield: 21%) of the above product. The total yield was 67%.

Provenance & Evidence