HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 5-(Trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-(Trifluoromethyl)acrylic acid | HCID 587694 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(Trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione | HCID 5638 | 64% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of α-trifluoromethylacrylic acid (350 mg; 2.5 mmoles), urea (170 mg: 2.8 mmoles) and acetic anhydride (1 ml) in dimethyl-formamide (2 ml) was stirred at 100° C. for 40 minutes. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethanol to give 290 mg (yield: 64%) of 5-trifluoromethyldihydrouracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581452 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-1c883b94be1c41d195264431ce4cbde1 |
| Source note | uspto-grants-1986_04 |