HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 5-(Heptafluoropropyl)dihydropyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | HCID 21277491 | HCID 21277491 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(Heptafluoropropyl)dihydropyrimidine-2,4(1H,3H)-dione | HCID 13457642 | 64% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of α-heptafluoropropylacrylic acid (240 mg; 1.0 mmole), urea (64 mg; 1.1 mmoles) and acetic anhydride (0.6 ml) was heated at 100° C. with stirring for 40 minutes. Then, ethanol (3 ml) was added to the reaction mixture to give 180 mg (yield: 64%) of 5-heptafluoropropyldihydrouracil as colorless crystals. m.p.: 223°-224 (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581452 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-9eb026844fda4258b6f30257cbd6f2de |
| Source note | uspto-grants-1986_04 |