Methyl iodide → 4H-1,2,4-Triazole, 3-methyl-5-(methylthio)-4-phenyl-

Participants

Reaction Steps

3-Mercapto-5-methyl-4-phenyl-1,2,4-triazole (19.1 g) was suspended in 200 ml of methanol, and 20 g of 28% sodium methylate was added thereto. After 10 minutes, 15 g of methyl iodide was added dropwise. They were reacted for 2 hours and then the methanol was distilled away. Upon extraction of the residue with ethyl acetate, 5-methyl-3-methylthio-4-phenyl-1,2,4-triazole was obtained.

Provenance & Evidence