Potassium Carbonate → HCID 23325341, compound

Participants

Reaction Steps

A mixture of 5.6 g (0.02 moles) of 2-(1-piperazinyl)-7-(4-pyridyl)[1,2,4]triazolo[1,5-a]pyrimidine (prepared as described in Example 47), 3.0 g (0.02 moles) of 4-bromobutyronitrile, 4.0 g of potassium carbonate and 50 ml of N,N-dimethylformamide was heated at reflux for 16 hours with stirring. The mixture was cooled and filtered. The filter was washed with N,N-dimethylformamide and the combined filtrate and wash was evaporated in vacuo to give a dark syrup. The syrup was dissolved in chloroform and passed through a pad of magnesium silicate washing with chloroform. The filtrate was evaporated to a syrup and crystallized from ethanol/ether. The precipitate was collected by filtration and washed with ether and gave 2.1 g of the desired product as golden crystals, mp 147°-148° C.

Provenance & Evidence