Isopropanol → HCID 23325345, compound

Participants

Reaction Steps

A mixture of 2.6 g (0.0093 moles) of 2-(1-piperazinyl)-7-(4-pyridyl)[1,2,4]triazolo[1,5-a]pyrimidine (prepared as described in Example 47), 1.4 g (0.0093 moles) of 2,3-epoxypropoxybenzene and 25.0 ml of 2-propanol was heated at reflux for 5 hours. The reaction mixture was evaporated in vacuo and gave a solid. The solid was dissolved in dichloromethane and passed through a pad of magnesium silicate. The effluent was evaporated to a solid. The solid was recrystallized from ethanol/ether/hexane, filtered, and washed with ether and gave 600 mg of the product of the Example as yellow crystals, mp 143°-145° C.

Provenance & Evidence