Dimethylformamide dimethyl acetal → HCID 53745215, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10.0 g (0.05 moles) of methyl 5-methyl-2-phenyl-4-imidazolyl ketone [A. C. Verones, et al., J. Het. Chem., 17, 1723 (1980)] and 45.0 ml of N,N-dimethylformamide dimethyl acetal was refluxed for 16 hours in an oil bath. The reaction mixture was cooled at -10° C., then filtered. The product was washed with 50 ml of cold ethanol, air dried and gave 4.6 g of 3-(dimethylamino)-1-(5-methyl-2-phenyl-1H-imidazol-4-yl)-2-propen-1-one as a yellow solid, mp 218°-222° C.

Provenance & Evidence