Trimethylsilyl iodide → HCID 13228938, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-1-(4-methoxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid (2 g) was suspended in 150 ml of acetonitrile, and 4 ml of trimethylsilyl iodide was added. The mixture was stirred in an argon stream at 90° C. for 48 hours. The reaction mixture was concentrated to dryness and the residue was shaken with 100 ml each of chloroform and water. The chloroform layer was washed with water and dried under reduced pressure. The residue was purified by column chromatography using 100 g of silica gel and recrystallization from acetone-diethyl ether to give 1.1 g of 4-chloro-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid as colorless needles, m.p. 193°-195° C. (decompn.).

Provenance & Evidence