Ethanol → HCID 13228938, compound

Participants

Reaction Steps

4-Chloro-5-cyanomethyl-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole (1 g) was dissolved in 10 ml of ethanol, and 10 ml of 2 N-sodium hydroxide was added. The mixture was boiled for 4 hours and evaporated to dryness, and the residue was shaken with 20 ml each of chloroform and water. The aqueous layer was washed with chloroform and 10 ml of 2N-hydrochloric acid was added. The resulting syrupy precipitate was recrystallized from aqueous ethanol to give 0.5 g of 4-chloro-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid as colorless needles, m.p. 192°-195° C. (decompn.).

Provenance & Evidence