HCID 23325448, compound → HCID 13228944, compound

Participants

Reaction Steps

1-(4-Benzyloxy-3-methylbenzyl)-4-chloro-5-cyanomethylimidazole (10 g) was boiled in 100 ml of trifluoroacetic acid for 15 minutes. The reaction mixture was then evaporated to dryness and the residue was chromatographed on a column of silica gel (100 g) using chloroform as an eluent. The desired fractions were combined and concentrated to about 20 ml to give 3.7 g of 4-chloro-5-cyanomethyl-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole as colorless prisms, m.p. 194°-196° C.

Provenance & Evidence