Acetic Anhydride → HCID 13228945, compound

Participants

Reaction Steps

4-Chloro-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid (1.1 g) was dissolved in 10 ml of pyridine, then 2 ml of acetic anhydride was added, and the mixture was stirred at room temperature for 2 hours and evaporated to dryness under reduced pressure. The residue was purified by column chromatography using 20 g of silica gel. The desired fractions were combined and evaporated to dryness under reduced pressure and the residue was recrystallized from aqueous ethanol to give 0.7 g of 4-chloro-1-(4-acetoxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid as colorless needles, m.p. 200°-203° C.

Provenance & Evidence