反应详情

57.0 g (1.056 mols) of sodium methylate are dissolved in 360 ml of methanol, and 208.4 g (0.96 mol) of 2-chloro-1-(4-chlorophenyl)-2-methylpropan-1-one are added dropwise to this solution at reflux temperature. The methanol is then removed by distillation. The residue is poured into ice water and the mixture is extracted with diethyl ether. The ether solution is washed with water, dried over Na2SO4 and concentrated. The resulting oil is purified by vacuum distillation.

1. temperatureat reflux temperature
2. customThe methanol is then removed by distillation
3. additionThe residue is poured into ice water
4. extractionthe mixture is extracted with diethyl ether
5. washThe ether solution is washed with water
6. dry with materialdried over Na2SO4
7. concentrationconcentrated
8. distillationThe resulting oil is purified by vacuum distillation