Allyl bromide → 2-Methyl-2-(morpholin-4-yl)-1-{4-[(prop-2-en-1-yl)sulfanyl]phenyl}propan-1-one

Participants

Reaction Steps

10 g (0.38 mol) of 1-(4-mercaptophenyl)-2-methyl-2-morpholinopropan-1-one, 5 g (0.041 mol) of freshly distilled allylbromide and 5.2 g (0.038 mol) of dry potassium carbonate are suspended in 50 ml of acetone and the mixture is heated to reflux temperature for 16 hours. After cooling, the solvent is removed by distillation, water and diethyl ether are added to the residue, and the water phase is extracted with ether. The organic phase is washed with 10% NaOH solution and water, dried over MgSO4 and concentrated. The oil which remains is distilled in a bulb tube at 180°-200° C./13 Pa. (Compound No. 23).

Provenance & Evidence