Anisole → HCID 131714617, compound

Participants

Reaction Steps

Z-Phe-Ser(Bzl)-Ala-LeuCH2Cl (0.71 g, 10.2 mmoles) was treated with a mixture of 15 mL of anhydrous HF and 1 mL of anisole in a commercial HF apparatus (Peptide Institute, Inc.). After 70 minutes at 0°, HF was removed by evaporation and the resulting residue was dried in vacuo over potassium hydroxide overnight. H-Phe-Ser-Ala-LeuCH2Cl.HF, 0.35 g, was obtained after triturating the residue with ether.

Provenance & Evidence