HCID 131714621, compound → HCID 131714620, compound

HRID 1380612Notes

Reaction equation

HRID 1380612 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][C@H:17]([C:27]([NH:29][C@H:30]([C:35]([CH2:37][Cl:38])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33])=[O:28])[CH2:18][O:19]CC1C=CC=CC=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(CCl)=O)CC(C)C)=O)C)=O)CO)=O)CC1C=CC=CC=1>>[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][C@H:17]([C:27]([NH:29][C@H:30]([C:35]([CH2:37][Cl:38])=[O:36])[CH2:31][CH:32]([CH3:33])[CH3:34])=[O:28])[CH2:18][OH:19])=[O:15])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 131714621HCID 131714621, compoundHCID 131714622HCID 131714622, compound

Product 1

HCID 131714620HCID 131714620, compound

Procedure

Z-Phe-Gly-Ser(Bzl)-LeuCH2Cl (0.98 g, 1.44 mmoles) was treated with anhydrous HF by a method substantially similar to that described for preparation of H-Phe-Ser-Ala-LeuCH2Cl.HF in Procedure F, yielding a hydrofluoride salt, H-Phe-Gly-Ser-LeuCH2Cl.HF (0.69 g).

Sources & evidence

ORD record
ord-df91f6b23884436baa14bc757cb6a78f
Source dataset
uspto-grants-1986_04
Patent number
US04582821

Reaction notes

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