HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → tert-Butyl [(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- | HCID 117439 | — |
| Reactant | HCID 54092844 | HCID 54092844 | — |
| Reactant | HCID 131714612 | HCID 131714612 | — |
| Product | tert-Butyl [(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamate | HCID 13919082 | — |
| Product | HCID 54092844 | HCID 54092844 | — |
Reaction Steps
Boc-ValCHN2 was prepared by a procedure substantially similar to that described for preparation of Boc-TyrCHN2 (Procedure C) except that Boc-Tyr-OH was replaced with Boc-Val-OH. Boc-ValCHN2 was treated with 3.45N ethanolic:HCl, as described in Procedure C, to give Boc-ValCH2Cl. After crystallization from hexane, product melted at 70°-73°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04582821 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-18e56fe6936441e7a4946c1a88892ae0 |
| Source note | uspto-grants-1986_04 |