HCID 53818886, compound → HCID 13519803, compound

HRID 1380652Notes

Reaction equation

HRID 1380652 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:13]=[CH:14][C:15](OCC)=[O:16])[C:8]=1[N+:20]([O-])=O)[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:8]=1[NH:20][C:15](=[O:16])[CH2:14][CH2:13]2)[CH3:2]

Participants

5

Reactant 2

HCID 53818886HCID 53818886, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13519803HCID 13519803, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-nitro-1,3-benzenediacrylic acid diethyl ester (3.5 g, 0.011 mole) in absolute ethanol (100 ml) is treated with hydrogen at 1 atmosphere pressure for 12 hours in the presence of 20% Pd/C. The mixture is filtered and concentrated at reduced pressure to yield 1,2,3,4-tetrahydro-2-oxo-8-quinolinepropanoic acid ethyl ester, mp 102°-103° C.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated at reduced pressure

Sources & evidence

ORD record
ord-eff62d38dc8c44a7a00299d1223782cc
Source dataset
uspto-grants-1986_04
Patent number
US04582909

Reaction notes

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