Butylamine → N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

HRID 1380746Notes

Reaction equation

HRID 1380746 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Cl.[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1>>[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 20184500HCID 20184500, compound

Product 1

HCID 13284538N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

Procedure

Prepared analogously to Example 51 from n-butylamine and 8-(2'-methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride. After the reaction finished, the aqueous phase wsa extracted with ethyl acetate. The residue remaining after the ethyl acetate phases were evaporated was digested with ethanol, subjected to suction filtration, and washed with water.

Workup

  1. extractionthe aqueous phase wsa extracted with ethyl acetate
  2. customwere evaporated
  3. filtrationsubjected to suction filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-26e7ee9c5273417092af8e873a3bc02f
Source dataset
uspto-grants-1986_04
Patent number
US04582837

Reaction notes

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