Ethanol → HCID 23324669, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 9.6 g (0.047 mol) of 6-chloro-4-chloromethyl-2-isopropyl-pyrimidine (see Example 61) in 40 ml of absolute ethanol is treated dropwise during 3 hours at 0° C. with a solution of 1.24 g (0.054 mol) of sodium in ethanol and the mixture is stirred at 0° C. for 3 hours and then at room temperature for 16 hours. The mixture is then taken up in diethyl ether and the solution is washed neutral with sodium chloride solution, dried over anhydrous sodium sulphate and freed from solvent under reduced pressure. After distillation of the oily residue in a high vacuum there is obtained 6-ethoxy-4-chloromethyl-2-isopropyl-pyrimidine, b.p. 52° C./0.07 mmHg, nD21 1.4955.

Provenance & Evidence