Allyl bromide → HCID 23324610, compound

HRID 1380835Notes

Reaction equation

HRID 1380835 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([CH:10]([CH3:12])[CH3:11])[N:4]=1.[CH2:13](Br)[CH:14]=[CH2:15]>>[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH2:15][CH:14]=[CH2:13])[N:6]=[C:5]([CH:10]([CH3:12])[CH3:11])[N:4]=1

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 178440239HCID 178440239, compound

Product 1

HCID 23324610HCID 23324610, compound

Procedure

4-Chloromethyl-6-hydroxy-2-isopropyl-pyrimidine is reacted with allylbromide analogously to the process described in Example 86 in order to produce 4-chloromethyl-2-isopropyl-6-(2-propenyloxy)-pyrimidine which is required as the starting material in Example 24. This product is obtained in the form of an oil, 1H-NMR (CDCl3): 1.30 (d, 2×CH3), 3.15 (m, CH), 4.55 (s, CH2), 4.93 (m, CH2), 5.37 (m, CH2), 6.12 (m, CH), 6.75 (s, CH).

Sources & evidence

ORD record
ord-4b75a929d50f4e09a3316f5ec590a577
Source dataset
uspto-grants-1986_04
Patent number
US04584295

Reaction notes

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