反应详情

A mixture of 6.5 g (0.036 mol) of 4-hydroxy-2-isopropyl-6-methyl-pyrimidine and 16.8 g (0.108 mol) of phosphorus oxychloride in 40 ml of chloroform is heated at reflux for 2 hours. The solution is then concentrated under reduced pressure, the residue is poured into water and the aqueous phase is extracted twice with 100 ml of n-hexane each time. The organic phase is dried over anhydrous sodium sulphate and subsequently evaporated. There is obtained 4-chloro-2-isopropyl-6-methyl-pyrimidine in the form of an orange oil, 1H-NMR (CDCl3): 1.32 (d, CH(CH3)2), 2.48 (s, CH3), 3.17 (m, CH(CH3)2), 7.03 (s, CH).

1. temperatureis heated
2. temperatureat reflux for 2 hours
3. concentrationThe solution is then concentrated under reduced pressure
4. additionthe residue is poured into water
5. extractionthe aqueous phase is extracted twice with 100 ml of n-hexane each time
6. dry with materialThe organic phase is dried over anhydrous sodium sulphate
7. customsubsequently evaporated