Triethylamine → n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide

Participants

Reaction Steps

While cooling with ice, a solution of 3,4-dimethoxyphenylacetyl chloride (485.2 g) in methylene chloride (1.1 liters) is added dropwise at 15°-20° C. to a solution of aminoacetaldehyde dimethyl acetal (246.2 ml) and triethylamine (315 ml) in methylene chloride (2.2 liters) and the mixture is stirred for one hour at 16°-18° C. It is then extracted several times with water, dried over magnesium sulphate and concentrated by evaporation. The oil obtained slowly crystallizes out. Yield: 608 g. Mp: 66°-69° C.

Provenance & Evidence