1-Bromo-3-chloropropane → HCID 13520688, compound

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Reaction Steps

First, 55% sodium hydride dispersion in oil (0.24 g, 5.5 mmol) is added to 7-bromo-8-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepine-2-one (1.35 g, 5 mmol) in dimethylsulphoxide (15 ml) and the mixture is stirred for 10 minutes at 35°-40° C. The solution is added dropwise to 1-bromo-3-chloropropane (0.79 g, 5.5 mmol) in dimethylsulphoxide (5 ml), with stirring. Then the mixture is stirred for 2 hours at ambient temperature, poured onto ice water and extracted four times with methylene chloride. The methylene chloride extracts are washed several times with water, dried and concentrated in vacuo.

Provenance & Evidence