反应详情

First, 2-[N-methyl-N-(2-cyano-ethyl)-amino]-7-methoxy-1,2,3,4-tetrahydronaphthalene (6.7 g, 0.0274 mol) is dissolved in methanol (80 ml) saturated with ammonia at 20° C., then Raney nickel (0.8 g) is added and the mixture is hydrogenated at 50° C. under hydrogen pressure (5 bar) for 3 hours. The catalyst is filtered off and the filtrate is evaporated by rotary evaporation. Yield: 5.4 g. Rf value: 0.25 (alumina, eluant: 95 parts by volume of methylene chloride+5 parts by volume of ethanol).

1. customis hydrogenated at 50° C. under hydrogen
2. customfor 3 hours
3. filtrationThe catalyst is filtered off
4. customthe filtrate is evaporated by rotary evaporation