反应详情

Here, 3,4-dichlorophenylacetic acid (66.7 g, 0.325 mol) is added in batches, with stirring at 5° C., to a mixture of fuming nitric acid (600 ml) and concentrated nitric acid (300 ml). The mixture is stirred for one hour while cooling is continued and the solution is allowed to rise to 20° C. over a period of a further 1.5 hours. The reaction mixture is poured onto ice, the precipitate is suction filtered, washed with ice water until neutral and then dried. Yield: 54.2 g. Mp: 119°-120° C.

1. temperaturewhile cooling
2. waitto rise to 20° C. over a period of a further 1.5 hours
3. additionThe reaction mixture is poured onto ice
4. filtrationfiltered
5. washwashed with ice water until neutral and
6. customthen dried