Dichloromethane → 1-[2-(2-Amino-4,5-dimethoxyphenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane

HRID 1380878Notes

Reaction equation

HRID 1380878 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]([CH2:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]([CH3:31])[CH:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][C:23]([O:29][CH3:30])=[CH:24][CH:25]=3)[CH2:20]2)=[O:13])=[C:5]([N+:32]([O-])=O)[CH:4]=1.C(Cl)Cl>C(O)C>[NH2:32][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[CH:7][C:6]=1[CH2:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]([CH3:31])[CH:19]1[CH2:28][CH2:27][C:26]2[C:21](=[CH:22][C:23]([O:29][CH3:30])=[CH:24][CH:25]=2)[CH2:20]1)=[O:13]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 537576601-[2-(4,5-Dimethoxy-2-nitro-phenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane

Product 1

HCID 543174201-[2-(2-Amino-4,5-dimethoxyphenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound here is prepared from 1-[2-(4,5-dimethoxy-2-nitro-phenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydro-naphth-2-yl)-amino]-propane (8.2 g, 0.0174 mol) analogously to Example S(c). Yield: 7.4 g. Rf value: 0.2 (alumina, eluant: 98 parts by volume of methylene chloride+2 parts by volume of ethanol).

Sources & evidence

ORD record
ord-d699eb93b0234a26b73d00c2bdc1d61f
Source dataset
uspto-grants-1986_04
Patent number
US04584293

Reaction notes

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