HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dimethoxy-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine → 1-[2-(2-Amino-4,5-dimethoxy-phenyl)-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dimethoxy-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 30658 | — |
| Reactant | 1-[2-(2-Amino-4,5-dimethoxyphenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane | HCID 54317420 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(2-Amino-4,5-dimethoxy-phenyl)-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane | HCID 23324572 | — |
Reaction Steps
The title compound here is prepared from 1-[2(-2-amino-4,5-dimethoxyphenyl)-1-oxo-ethylamino]-3-[N-methyl-N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane (6.73 g, 0.0153 mol) analogously to Example R(e). Yield: 4.2 g. Rf value: 0.2 (alumina, eluant: 95 parts by volume of methylene chloride+5 parts by volume of ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584293 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-59b6913629b24311a227e749472a4ef0 |
| Source note | uspto-grants-1986_04 |