HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → Benzenepropanoic acid, b-(nitromethyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 2-Propenoic acid, 3-phenyl-, methyl ester | HCID 7644 | — |
| Reactant | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Benzenepropanoic acid, b-(nitromethyl)-, methyl ester | HCID 10537045 | — |
Reaction Steps
A mixture of 300 g of cinnamic acid methyl ester, 500 g of nitromethane and 39 g of tetramethylguanidine is allowed to stir at room temperature for 72 hours. The solution is diluted with diethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-phenylbutanoic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584313 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-8047cb0e83d14c57a0028cc1464f6079 |
| Source note | uspto-grants-1986_04 |