HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Nitro-3-phenylheptanedioic acid dimethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | Benzenepropanoic acid, b-(nitromethyl)-, methyl ester | HCID 10537045 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 4-Nitro-3-phenylheptanedioic acid dimethyl ester | HCID 13649246 | — |
Reaction Steps
A solution of 356 g of 4-nitro-3-phenylbutanoic acid methyl ester, 138 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-phenylheptanedioic acid dimethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584313 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-3f4c7e6ec30141ae967858d614e0af35 |
| Source note | uspto-grants-1986_04 |