HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Nitro-3-(3,4-dichlorophenyl)heptanedioic acid dimethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | 4-Nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester | HCID 21472502 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 4-Nitro-3-(3,4-dichlorophenyl)heptanedioic acid dimethyl ester | HCID 53793491 | — |
Reaction Steps
A solution of 350 g of 4-nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester, 118 g of methyl acrylate and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-(3,4-dichlorophenyl)heptanedioic acid dimethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584313 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-7d098911b7184e22a70340d28e7a891b |
| Source note | uspto-grants-1986_04 |