HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → 5-Hydroxymethyl-2-mercapto-1-benzylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | Dihydroxyacetone dimer | HCID 4180364 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Hydroxymethyl-2-mercapto-1-benzylimidazole | HCID 178519845 | — |
Reaction Steps
n-Butanol (50 ml), glacial acetic acid (25 g), dihydroxyacetone dimer (21.0 g), potassium thiocyanate (34.1 g) and benzylamine (28.0 g) are combined at room temperature. The mixture is stirred at room temperature for 50 hours and the product is filtered. A light brown product is obtained, 35.0 g (68.2%), m.p. 229°-231° C. The NMR spectrum shows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584383 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-b47689e520434a2d94579990bd6f6664 |
| Source note | uspto-grants-1986_04 |