HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 1-Benzyl-5-hydroxymethyl-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Hydroxymethyl-2-mercapto-1-benzylimidazole | HCID 178519845 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzyl-5-hydroxymethyl-1H-imidazole | HCID 2773235 | — |
Reaction Steps
1-Benzyl-2-mercapto-5-hydroxymethyl-imidazole (7.5 g) is added in small portions to a mixture of water (18 ml) and concentrated nitric acid (7.5 g) at 35° C. The mixture is stirred for 3 hours and the pH of the reaction mixture adjusted to 9-10 with sodium hydroxide. 1-Benzyl-5-hydroxymethyl-imidazole is obtained, 3.8 g (60%), m.p. 131°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584383 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-f655f798f4df46de975004a0485c55f6 |
| Source note | uspto-grants-1986_04 |