HCID 13094267, compound → HCID 13094268, compound

HRID 1381009Notes

Reaction equation

HRID 1381009 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH3:15])[C:7]([CH2:10][CH2:11][CH2:12][C:13]#[N:14])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH3:15])[C:7]([CH2:10][CH2:11][CH2:12][C:13]#[N:14])=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 13094267HCID 13094267, compound

Product 1

HCID 13094268HCID 13094268, compoundYield 93.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

5-Nitro-2-(3-cyanopropyl)-3-methylpyridine (5.9 g) was hydrogenated in ethanol (150 ml) with palladium on charcoal (0.59 g of 10%) at 140 kPa, for 2.5 hrs. The filtered solution was concentrated to dryness, the residue was triturated with ether to give 5-amino-2-(3-cyanopropyl)-3-methylpyridine (4.70 g) m.p. 103°-105° C.

Workup

  1. concentrationThe filtered solution was concentrated to dryness
  2. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-8a606c3055e647a0a6492542ff268071
Source dataset
uspto-grants-1986_04
Patent number
US04584381

Reaction notes

Loading…