Hydrogen Bromide → 4-(5-Bromo-3-methyl-2-pyridinyl)butylamine

Participants

Reaction Steps

A solution of sulphur trioxide (150 ml) in 1,1,2-tri-fluorotrichloroethane (350 ml) was added over ca 30 min. to a suspension of 2-(4-aminobutyl)-3-methylpyridine dihydrobromide (17 g) [prepared by passing hydrogen bromide gas through a solution of the amine in dichloromethane] in 1,1,2-trifluorotrichloroethane (100 ml) and the mixture was heated under reflux for ca 16 hr. The solvent was removed by distillation and unbrominated starting material was removed by acetylation as described in Example 1(h) to yield 5-bromo-2-(4-amino-butyl)-3-methylpyridine (6.53 g) as an oil.

Provenance & Evidence