5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one → HCID 13094276, compound

HRID 1381017Notes

Reaction equation

HRID 1381017 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1.[N+](N[C:18]1[NH:23][C:22](=[O:24])[C:21]([CH2:25][C:26]2[CH:27]=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=2)=[CH:20][N:19]=1)([O-])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:18]2[NH:23][C:22](=[O:24])[C:21]([CH2:25][C:26]3[CH:27]=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=3)=[CH:20][N:19]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 30183605-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-oneHCID 13094273HCID 13094273, compound

Product 1

HCID 13094276HCID 13094276, compoundYield 28.3%

Procedure

Reaction of 5-chloro-2-(4-aminobutyl)-3-methyl-pyridine [from Example 5(a)] (1.0 g) with 2-nitroamino-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone (1.23 g) under conditions analogous to those described in Example 1(f) gave 2-[4-(5-chloro-3-methylpyrid-2-yl)butylamino]-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone (0.53 g) m.p. 140°-141° C.

Sources & evidence

ORD record
ord-8984da5e74654df9b311dc0d7337ceb4
Source dataset
uspto-grants-1986_04
Patent number
US04584381

Reaction notes

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