反应详情

温度

0 °C

16.6 g of 1-benzyloxy-2-propanol and 10.6 g of triethylamine were dissolved in 200 ml of toluene, then cooled to 0° C. To this solution was dropwise added a solution of 34.7 g of 2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]-propionyl chloride in 80 ml of toluene at 0° to 5° C. with stirring. After the dropwise addition, the mixture was gradually heated and, at 40° to 50° C., it was stirred for one hour to complete the reaction. After cooling to room temperature, it was washed successively with 1% strength by weight sodium hydroxide aqueous solution and water, followed by drying. Upon distilling off toluene under reduced pressure, there were obtained 43.3 g of pale yellow, viscous, oily 1-methyl-2-benzyloxyethyl 2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]propionate. nD20 1.5710

1. additionAfter the dropwise addition
2. temperaturethe mixture was gradually heated and, at 40° to 50° C.
3. stirringit was stirred for one hour
4. customthe reaction
5. temperatureAfter cooling to room temperature
6. washit was washed successively with 1% strength by weight sodium hydroxide aqueous solution and water
7. customby drying
8. distillationUpon distilling off toluene under reduced pressure