Hydrochloric Acid → HCID 19777516, compound

Participants

Reaction Steps

3,5-Dinitrobenzamide (XIX) (85.0 g, 402 mMoles, Aldrich) was added to a suspension of 10% Pd/C (8.5 g) in concentrated HCl (74 ml) and water (730 ml). The mixture was hydrogenated at about 60 psi in a Parr hydrogenation apparatus until hydrogen was no longer being consumed (3 hours). TLC (silica, 80 chloroform/20 methanol) indicated that no starting material remained, and that to a single product with an Rf of 0.23 had occurred. The solution, which contained the product (XIX), was then filtered through a celite pack, the pack was washed with 300 ml water, and the filtrate and washings combined and used for the subsequent iodination.

Provenance & Evidence