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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1381112Generated: November 3, 2026

Methyl iodide → 5-Fluoro-2-methoxyaniline

https://huagongshe.com/reaction/1381112

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactant5-Fluoro-2-nitrophenolHCID 9937—
Reactant5-Fluoro-2-nitroanisoleHCID 2779250—
Product5-Fluoro-2-methoxyanilineHCID 22310598%

Reaction Steps

Reduction of 1-fluoro-3-methoxy-4-nitrobenzene (0.11 mol) (prepared by methylation of 5-fluoro-2-nitrophenol with methyl iodide was carried out according to Step (b) of Example XII to provide 14.8 g (98% yield) of 5-fluoro-2-methoxyaniline used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04585773
Source datasetuspto-grants-1986_04
ORD IDord-836ef1bf3bbc457196e8dba13ccc57d1
Source noteuspto-grants-1986_04