Nitric Acid → HCID 178517283, compound

HRID 1381116Notes

Reaction equation

HRID 1381116 reaction equation
OS(O)(=O)=O.[N+:6]([O-:9])(O)=[O:7].[O:10]=[C:11]1[N:20]2[CH2:21][CH2:22][N:23]=[C:19]2[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH:12]1>>[N+:6]([C:16]1[CH:15]=[CH:14][C:13]2[NH:12][C:11](=[O:10])[N:20]3[CH2:21][CH2:22][N:23]=[C:19]3[C:18]=2[CH:17]=1)([O-:9])=[O:7]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178517111HCID 178517111, compound

Product 1

HCID 178517283HCID 178517283, compound

Procedure

7 ml of concentrated H2SO4 were added, whilst cooling, to 5 ml of 98% strength HNO3. 9.3 g (0.05 mol) of 5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline were added in portions at 0° to 5° C. to this mixture, and the latter was stirred for 2 hours at room temperature. The reaction mixture was then poured into ice water, and the precipitated deposit was filtered off under suction. It was neutralised in water with NaHCO3, the mixture being heated to boiling for a short time. After the mixture had been cooled, the precipitate was again filtered off under suction, washed with ethanol and ether, and dried.

Workup

  1. filtrationthe precipitated deposit was filtered off under suction
  2. temperaturethe mixture being heated
  3. temperatureAfter the mixture had been cooled
  4. filtrationthe precipitate was again filtered off under suction
  5. washwashed with ethanol and ether
  6. customdried

Sources & evidence

ORD record
ord-ec02ed476fb447eb9800254d3a99ba72
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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